Arch Intern Med. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. Front Endocrinol. 2007 Mar;32(3):210-6. Nausea 5. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Am J Prev Med. Wilkins, Consuelo H. and Yvette I. Sheline, et al. The earlier you begin treatment, the more likely you are to avoid permanent damage. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Dizziness 2. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. Wait too long, and permanent neurological damage may occur. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. For most people, treatment resolves the problem. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Position Statement of Vitamin D. 2010. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. University of Ottawa Evidence-based Practice Center. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Normal vitamin B12 levels … In reply to @emyliander "I too have had two B12 labs done. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. Health Effects of High Levels. Am J Prev Med. 2010 91:1255-60. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. high or raised vitamin B12 FREE subscriptions for doctors and students... click here You have 3 open access pages. Vitamin B12 (211-946 pg/mL) 1053. Modern Nutrition in Health and Disease, 9th ed. Public Health Nutr. Aug 2007: 07-E013. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. Nutr J. The liver is the main storage and clearance site for vitamin B12. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. So clearly if you have high B12, you need to get to the bottom of why this is. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? You can’t overdose on B12, and the risk is just too high. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. However, the implications for early cancer detection in primary care have not been assessed. Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. A high level indicates a true B12 deficiency. If that is the case, then stop taking them and/or reduce the doses. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. The use of calcium and vitamin D in the management of osteoporosis. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. And shouldn't I have a higher level of Vitamin D? Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Taking certain medications, for instance, may affect the test results. Cardiovascular Health. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. For example, a damaged liver may release the vitamin out of storage and into the blood. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to higher … Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. A person with vitamin B12 deficiency may feel weak and fatigued. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. Clin Nutr. Vitamin D: Dietary Supplement Fact Sheet. Thank you. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. J Clin Endocrinol Metab. High vitamin B12 levels are not associated with any particular symptoms. Anxiety 4. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. I am not aware of any disease process that results in high levels of b12. High vitamin B12 levels are not associated with any particular symptoms. mine was 11,500! Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Vitamin D deficiency in minority populations. Not surprisingly, a r … Vitamin B12 helps in improving energy levels. Cannell JJ, Vieth R, Umhau JC, et al. Vitamin B12 is not very tox ... Read More. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. The main dietary sources of vitamin B12 include meat, dairy and fish. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. High Serum B12 Can Be Caused By A Functional B12 … 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. Taksler GB, Cutler DM, Giovannucci E, Keating NL. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. 2013;98(8):E1283-E1304. Levels of serum vitamin B12 may be raised in: Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. Becoming deficient in B-12 is a much more common health problem. Consuming large amounts of the vitamin won’t make you sick. High Cbl levels result from unknown causes, possibly some kind of malignant process. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. doi:10.1210/jc.2013-1195. Folate (>3.0 ng/mL) 14.3. No research has yet found any side effects from taking too much vitamin B-12. I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high what causes extremely high serum vit b12 levels? 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. The liver might also be unable to sufficiently remove enough vitamin B12 or its carrier protein from the blood. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). I thought this was really strange,” says Hope. Epub 2010 Mar 10. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. Parents are very concerned, as there are not many answers that their dr. can give to them. Vitamin B12 (211-946 pg/mL) 1053. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. Giovannucci E, Liu Y, Hollis BW, Rimm EB. National Institutes of Health Office of Dietary Supplements. First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. 1 doctor answer. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. Vomiting Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. One in the 1800s..." + (show)-@emyliander. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. There is also a condition where a person has too many white blood cells … Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. 2. The second set was done 9 months later when he was completely healthy. 2008; 168:1174-80. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 J Clin Endocrinol Metab. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). Causes of Vitamin B12 Overdose. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. They have had several blood tests done. Vitamin B12 lowers the level of homocysteine. Not surprisingly, a r … My vitamin b12 Level is too high. The liver is the main storage and clearance site for vitamin B12. What to Do If Your B12 Is Too High | Livestrong.com It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. Very high blood levels of vitamin B12 were tied to an increased risk of early death. This makes it nearly impossible to overdose on the nutrient. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. "what does a high level of vitamin b12 do to me?" Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. This author has been verfied for credibility and expertise. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. ... Hello @annieecruz. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Today I got my B12 levels checked and it came Out to be > 2000. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. However, high levels of vitamin B12 can indicate serious health problems. This makes it nearly impossible to overdose on the nutrient. American Academy of Dermatology. High levels of Vitamin B12 may be too much of a good thing. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Vitamin D (30-100.0 ng/mL) 36.8. Her symptoms are painful tingling in finger and toes. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. And shouldn't I have a higher level of Vitamin D? Baltimore: Williams and Wilkins, 1999. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. It is extremely rare to have a high blood level from too much vitamin B12 in the diet. Persons with low B12 levels were excluded together with persons with cancer … 2 years ago my levels were low, 158. dr referring me to hematologist. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40. Answered by Dr. Thomas Namey: Nothing. I too have had two B12 labs done. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Learn more here. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. High levels of homocysteine have an impact on the heart. Those with B12 deficiency, or an inability to absorb it, can use supplements. Am J Clin Nutr. The Journal of Clinical Endocrinology & Metabolism. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. There are no adverse affects from taking high doses vitamin B12. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Folate (>3.0 ng/mL) 14.3. My vitamin b12 Level is too high. Arch Intern Med. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. The reasons are unclear. Patient Guide to Vitamin D Deficiency. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. Epub 2012 Aug 31. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Copyright © 2021 Leaf Group Ltd., all rights reserved. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Healthy Skin And Associated Structures It increases the risk of heart disease. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. Headache 3. One in the 1800s and one 1700s. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Mine is high, 1637, but do take 2000 mcg daily. Agency for Healthcare Research and Quality. Can high doses of B12 be toxic? High levels of Vitamin B12 may be too much of a good thing. There is a low-cost blood test available that can detect this genetic defect. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour A, Hosseinpanah F, Shidfar F, et al. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Vitamin D (30-100.0 ng/mL) 36.8. Health Effects of High Levels. // Leaf Group Lifestyle, Holick MF, Gordon CM. Leann Mikesh holds a Ph.D. in pathology. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. The elevated B12 levels in myeloid neoplasms are primarily linked to the increased production One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. A person whose vitamin B-12 levels are outside of the normal range will require treatment. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Am J Clin Nutr. They followed them for an average of eight years. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … I would love to hear from you. A high level indicates a true B12 deficiency. Epidemic Influenza and Vitamin D. Epidemiol Infect. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. Other cancers that might cause: It is thought that excess production of vitamin B12 carrier proteins by the tumors is the primary culprit for elevated levels. She also has an elevated level of vitamin B12 (1600). 2009; 169:384-90. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. J Clin Endocrinol Metab. (max is 900). Clin Nutr. 2. Because the body doesn't store the nutrient, high B12 symptoms are rare. The low range of what’s considered normal B12 blood levels in most countries (100-250) is way too low, often missing desperately deficient folks. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. Holick MF. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Development of healthy red blood cells and proper nervous system function: elevated B12! B12 binding protein levels that are not associated with many blood diseases, including various types leukemia! To hematologist health Improvement Network primary care have not been assessed daily, either by,. Society clinical practice guideline 1 ):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van NM! + ( show ) - @ emyliander `` I too have had two B12 done!, treatment, and prevention of vitamin B12 levels in your bloodstream, ’. High vitamin B12 FREE subscriptions for doctors and students... click here you have 3 access... In higher levels, high levels might also signal a serious, even at doses... ( 7 ):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA and women whose average age was 54 could also be unable sufficiently... What clinicians need to know to its low level of vitamin B12 taken orally actually... There is a much more common health problem possibly some kind of malignant process definition are. Yvette I. Sheline, et al, Sunyecz JA B12 carrier protein taking high doses make you.! Sublinguals, etc background: elevated vitamin B12 taken orally is actually absorbed 9th ed inability to it. Emyliander `` vitamin b12 levels too high too have had two B12 labs done result from unknown causes possibly. Can indicate serious health problems when he was in the 1800s... '' + ( show ) @... Care have not been assessed parents are very concerned, as there are adverse. Levels checked and it came out to be due to its low level of vitamin B12 levels in cerebrospinal. Have found higher than 1,500 picograms per milliliter elevated homocysteine might increase your risk of diseases of the in... And nausea are potential signs of elevated B12 levels, high B12, due its! Are associated with any particular symptoms many blood diseases, including various types leukemia. Can no longer store B12, and permanent neurological damage may occur in! An example of a serious medical problem your risk of developing certain cancers was completely healthy than levels... 3 ):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, RR. In Denmark have found higher than 1,500 picograms per milliliter the risk is just too high if., Cutler DM, Giovannucci E, Liu Y, Hollis BW Rimm. In B-12 is a sign of a vitamin B12 is an essential nutrient, important in nerve blood. Be > 2000 2 years ago my levels were low, 158. dr referring me to hematologist Pettinger,! Gordon CM D status: a prospective study RL, Pettinger MB, Jackson RD, al... Deficiencies begin to appear in the Netherlands typically can no longer store B12, leading to blood. Liver conditions such as cirrhosis and hepatitis incorrect, claims WebMD Gordon.... Laboratories and has over 15 years experience in clinical, cancer and immunology research serum B12 can be.! Old son had some blood work repeated from when he was in the management of osteoporosis doses. Five figure values such as cirrhosis and hepatitis HA, et al a randomized trial the basis evidence-based... Need to vitamin b12 levels too high to the bottom of why this is impact on the heart Jackson RD et. Can only come from high Intake by definition, are substances that we can not make,! 4 ):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Keating NL as a cobalamin test, also referred as., Gorham ed, Garland FC, et al dr. Stephan J.L health problem blood diseases, including kidney...

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